Class G (Samonella typhimurium DT104 - tetA and tetR genes)
ID AF071555 standard; DNA; PRO; 13077 BP.
XX
AC AF071555;
XX
NI g4063850
XX
DT 29-DEC-1998 (Rel. 58, Created)
DT 29-DEC-1998 (Rel. 58, Last updated, Version 1)
XX
DE Salmonella typhimurium DT104 antibiotic resistance gene cluster,
DE complete sequence.
XX
KW .
XX
OS Salmonella typhimurium DT104
OC Bacteria; Proteobacteria; gamma subdivision; Enterobacteriaceae;
OC Salmonella; Salmonella typhimurium.
XX
RN [1]
RP 1-13077
RA Briggs C.E., Fratamico P.M.;
RT "Molecular Characterization of an Antibiotic Resistance Gene Cluster of
RT Salmonella typhimurium DT104";
RL Unpublished.
XX
RN [2]
RP 1-13077
RA Briggs C.E., Fratamico P.M.;
RT ;
RL Submitted (11-JUN-1998) to the EMBL/GenBank/DDBJ databases.
RL Microbial Food Safety Unit, USDA, ARS, ERRC, 600 E. Mermaid Lane,
RL Wyndmoor, PA 19038, USA
XX
FH Key Location/Qualifiers
FH
FT source 1..13077
FT /organism="Salmonella typhimurium DT104"
FT /note="Salmonella typhimurium phage type DT104"
FT /strain="H3380"
FT repeat_region 666..3785
FT /note="similar to Corynebacterium glutamicum pCG4 integron
FT InCg sequence deposited in GenBank Accession Number Y14748"
FT CDS complement(802..1815)
FT /codon_start=1
FT /db_xref="PID:g4063851"
FT /transl_table=11
FT /product="integrase"
FT /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLPTEQAYVHWVRAFI
FT RFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQEI
FT GRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDFDHG
FT TIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALERKYPR
FT AGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATPHTLRH
FT SFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLTSER"
FT CDS 1961..2752
FT /codon_start=1
FT /db_xref="PID:g4063852"
FT /transl_table=11
FT /gene="aadA2"
FT /function="resistance to streptomycin/spectinomycin"
FT /product="streptomycin/spectinomycin adenyltransferase"
FT /translation="MRVAVTIEISNQLSEVLSVIERHLESTLLAVHLYGSAVDGGLKPY
FT SDIDLLVTVAVKLDETTRRALLNDLMKASAFPGESETLRAIEVTLVVHDDIIPWRYPAK
FT RELQFGEWQRNDILAGIFEPAMIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLF
FT EALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQP
FT VLLEAKQAYLGQKEDHLASRADHLEEFIRFVKGEIIKSVGK"
FT misc_difference 2174
FT /note="Corynebacterium glutamicum pCG4 integron InCg"
FT /replace="g"
FT /gene="aadA2"
FT misc_feature 2754..2813
FT /note="similar to 59-base element integron cassette
FT boundary"
FT CDS 2916..3263
FT /codon_start=1
FT /db_xref="PID:g4063860"
FT /transl_table=11
FT /function="resistance to quaternary ammonium compound and
FT disinfectants"
FT /product="qac delta E"
FT /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFY
FT FLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSP
FT SWKSLRRPTPW"
FT misc_feature 3257..3785
FT /note="corresponds to dihydropteroate synthase partial
FT coding sequence"
FT CDS 4445..5659
FT /codon_start=1
FT /db_xref="PID:g4063853"
FT /note="similar to PP-FLO encoded by GenBank Accession
FT Number D37826 and CmlA"
FT /transl_table=11
FT /function="resistance to chloramphenicol"
FT /product="unknown"
FT /translation="MTTTRPAWAYTLPAALLLMAPFDILASLAMDIYLPVVPAMPGILN
FT TTPAMIQLTLSLYMVMLGVGQVIFGPLSDRIGRRPILLAGATAFVIASLGAAWSSTAPA
FT FVAFRLLQAVGASAMLVATFATVRDVYANRPEGVVIYGLFSSMLAFVPALGPIAGALIG
FT EFLGWQAIFITLAILAMLALLNAGFRWHETRPLDQVKTRRSVLPIFASPAFWVYTVGFS
FT AGMGTFFVFFSTAPRVLIGQAEYSEIGFSFAFATVALVMIVTTRFAKSFVVRWGIAGCV
FT ARGMALLVCGAVLLGIGELYGSPSFLTFILPMWVVAVGIVFTVSVTANGALAEFDDIAG
FT SAVAFYFCIQSLIVSIVGTLAVTLLNGDTAWPVICYATAMAVLVSLGLALLRSRDAATE
FT KSPVV"
FT CDS complement(5866..6492)
FT /codon_start=1
FT /db_xref="PID:g4063854"
FT /transl_table=11
FT /gene="tetR"
FT /function="regulation of tetracycline resistance"
FT /product="tetracycline repressor protein"
FT /translation="MTKLDKGTVIAAALELLNEVGMDSLTTRKLAERLKVQQPALYWHF
FT QNKRALLDALAEAMLAERHTRSLPEENEDWRVFLKENALSFRTALLSYRDGARIHAGTR
FT PTEPNFGTAETQIRFLCAEGFCPKRAVWALRAVSHYVVGSVLEQQASDADERVPDRPDV
FT SEQAPSSFLHDLFHELETDGMDAAFNFGLDSLIAGFERLRSSTTD"
FT CDS 6644..7771
FT /codon_start=1
FT /db_xref="PID:g4063855"
FT /transl_table=11
FT /gene="tetA"
FT /function="tetracycline resistance"
FT /product="tetracycline resistance protein"
FT /translation="MGLGLIMPVLPTLLRELVPAEQVAGHYGALLSLYALMQVVFAPML
FT GQLSDSYGRRPVLLASLAGAAVDYTIMASAPVLWVLYIGRLVSGVTGATGAVAASTIAD
FT STGEGSRARWFGYMGACYGAGMIAGPALGGMLGGISAHAPFIAAALLNGFAFLLACIFL
FT KETHHSHGGTGKPVRIKPFVLLRLDDALRGLGALFAVFFIIQLIGQVPAALWVIYGEDR
FT FQWNTATVGLSLAAFGATHAIFQAFVTGPLSSRLGERRTLLFGMAADATGFVLLAFATQ
FT GWMVFPILLLLAAGGVGMPALQAMLSNNVSSNKQGALQGTLTSLTNLSSIAGPLGFTAL
FT YSATAGAWNGWVWIVGAILYLICLPILRRPFATSL"
FT CDS complement(10433..11086)
FT /codon_start=1
FT /db_xref="PID:g4063856"
FT /transl_table=11
FT /product="GroEL-like/integrase fusion protein"
FT /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLPTEQAYVHWVRAFI
FT RFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWQGIN
FT EDQNLGIAITRRALEAPLRAIVANAGEEPSVIVANVKAGEGSYGYNAATGEFGDMIAMG
FT ILDPTKVTRSALQHAASVAGLAITTEVVVAEVPKKEEPAMPGAGGMGGMGGMDF"
FT misc_feature 10433..10785
FT /note="similar to GroEL"
FT misc_feature 10786..11086
FT /note="similar to integrase"
FT CDS 11292..12158
FT /codon_start=1
FT /db_xref="PID:g4063857"
FT /transl_table=11
FT /product="beta-lactamase Pse-1 precursor"
FT /translation="MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVL
FT DTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVI
FT EKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPD
FT LNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPA
FT GWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFD
FT VYTSQSR"
FT misc_feature 12210..12272
FT /note="similar to 59-base element integron cassette
FT boundary"
FT CDS 12375..12722
FT /codon_start=1
FT /db_xref="PID:g4063858"
FT /transl_table=11
FT /function="resistance to quaternary ammonium compound and
FT disinfectants"
FT /product="qac delta E"
FT /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFY
FT FLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSP
FT SWKSLRRPTPW"
FT CDS 12716..>13077
FT /codon_start=1
FT /db_xref="PID:g4063859"
FT /note="resistance to sulphonamides"
FT /transl_table=11
FT /gene="sulI"
FT /product="dihydropteroate synthase"
FT /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVG
FT PAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQ
FT GFPDPALYPDIAEADC"
XX
SQ Sequence 13077 BP; 2600 A; 3734 C; 3792 G; 2951 T; 0 other;
TCTAGATACA CCATATGGCC TAGCAACATC AGATACAGGA ATAGAACCAT CTTTGAGTAA 60
TGCCCTAATC TCCCTGATAT CCTTTTTCTG TAACTTTGGC TTCCGCCCAC CCAAGCGACC 120
GCGAGCTCTT GCGGCTTCCA ATCCCGCCTT GGTACGTTCG CTAATCAAAT TTCGCTCAAA 180
TTCAGCCAAA GCAGCAAACA CATGAAAAAC CAGCTTTCCA GAAGCACTGT TCGTTTCAAT 240
CTGTTCTTGT AGGCTCAGAA ATCCAATCCG TCGCTCATCA ACCAGATGGG TAACAACGCT 300
CACCAAGTCT GCCAAACTAC GGCCTAACCT ATCCAGCCTC CAAACGACCA ACGTATCCCC 360
AGGTCTAAGA GCCTTTAAGC AGTTATCAAG TTCGGGTCTA GCGGCATTCT TCCCACTGGC 420
CTTGTCCTCG TAAATGATCT CGCAACCAGC AGCAGCCAAC GCATCTCTCT GCAAATGCAG 480
GTTCTGATCG TCGGTTGAAA CCCTAGCGTA GCCAATTTTT TGATTCATGT ACGTTTTTTT 540
AACATAGAAT TTTATACAAG TATTTTAACA TGTATATAGA TTAAATTCCA ATCAACTTGT 600
GTCGTTTTCA GAAGACGGCT GCACTGAACG TCAGAAGCCG ACTGCACTAT AGCAGCGGAG 660
GGGTTGGATC CATCAGGCAA CGACGGGCTG CTGCCGGCCA TCAGCGGACG CAGGGAGGAC 720
TTTCCGCAAC CGGCCGTTCG ATGCGGCACC GATGGCCTTC GCGCAGGGGT AGTGAATCCG 780
CCAGGATTGA CTTGCGCTGC CCTACCTCTC ACTAGTGAGG GGCGGCAGCG CATCAAGCGG 840
TGAGCGCACT CCGGCACCGC CAACTTTCAG CACATGCGTG TAAATCATCG TCGTAGAGAC 900
GTCGGAATGG CCGAGCAGAT CCTGCACGGT TCGAATGTCG TAACCGCTGC GGAGCAAGGC 960
CGTCGCGAAC GAGTGGCGGA GGGTGTGCGG TGTGGCGGGC TTCGTGATGC CTGCTTGTTC 1020
TACGGCACGT TTGAAGGCGC GCTGAAAGGT CTGGTCATAC ATGTGATGGC GACGCACGAC 1080
ACCGCTCCGT GGATCGGTCG AATGCGTGTG CTGCGCAAAA ACCCAGAACC ACGGCCAGGA 1140
ATGCCCGGCG CGCGGATACT TCCGCTCAAG GGCGTCGGGA AGCGCAACGC CGCTGCGGCC 1200
CTCGGCCTGG TCCTTCAGCC ACCATGCCCG TGCACGCGAC AGCTGCTCGC GCAGGCTGGG 1260
TGCCAAGCTC TCGGGTAACA TCAAGGCCCG ATCCTTGGAG CCCTTGCCCT CCCGCACGAT 1320
GATCGTGCCG TGATCGAAAT CCAGATCCTT GACCCGCAGT TGCAAACCCT CACTGATCCG 1380
CATGCCCGTT CCATACAGAA GCTGGGCGAA CAAACGATGC TCGCCTTCCA GAAAACCGAG 1440
GATGCGAACC ACTTCATCCG GGGTCAGCAC CACCGGCAAG CGCCGCGACG GCCGAGGTCT 1500
TCCGATCTCC TGAAGCCAGG GCAGATCCGT GCACAGCACC TTGCCGTAGA AGAACAGCAA 1560
GGCCGCCAAT GCCTGACGAT GCGTGGAGAC CGAAACCTTG CGCTCGTTCG CCAGCCAGGA 1620
CAGAAATGCC TCGACTTCGC TGCTGCCCAA GGTTGCCGGG TGACGCACAC CGTGGAAACG 1680
GATGAAGGCA CGAACCCAGT GGACATAAGC CTGTTCGGTT GGTAAGCTGT AATGCAAGTA 1740
GCGTATGCGC TCACGCAACT GGTCCAGAAC CTTGACCGAA CGCAGCGGTG GTAACGGCGC 1800
AGTGGCGGTT TTCATGGCTT GTTATGACTG TTTTTTTGTA CAGTCTATGC CTCGGGCATC 1860
CAAGCAGCAA GCGCGTTACG CCGTGGGTCG ATGTTTGATG TTATGGAGCA GCAACGATGT 1920
TACGCAGCAG GGCAGTCGCC CTAAAACAAA GTTAGACATC ATGAGGGTAG CGGTGACCAT 1980
CGAAATTTCG AACCAACTAT CAGAGGTGCT AAGCGTCATT GAGCGCCATC TGGAATCAAC 2040
GTTGCTGGCC GTGCATTTGT ACGGCTCCGC AGTGGATGGC GGCCTGAAGC CATACAGCGA 2100
TATTGATTTG TTGGTTACTG TGGCCGTAAA GCTTGATGAA ACGACGCGGC GAGCATTGCT 2160
CAATGACCTT ATGAAGGCTT CGGCTTTCCC TGGCGAGAGC GAGACGCTCC GCGCTATAGA 2220
AGTCACCCTT GTCGTGCATG ACGACATCAT CCCGTGGCGT TATCCGGCTA AGCGCGAGCT 2280
GCAATTTGGA GAATGGCAGC GCAATGACAT TCTTGCGGGT ATCTTCGAGC CAGCCATGAT 2340
CGACATTGAT CTAGCTATCC TGCTTACAAA AGCAAGAGAA CATAGCGTTG CCTTGGTAGG 2400
TCCGGCAGCG GAGGAATTCT TTGACCCGGT TCCTGAACAG GATCTATTCG AGGCGCTGAG 2460
GGAAACCTTG AAGCTATGGA ACTCGCAGCC CGACTGGGCC GGCGATGAGC GAAATGTAGT 2520
GCTTACGTTG TCCCGCATTT GGTACAGCGC AATAACCGGC AAAATCGCGC CGAAGGATGT 2580
CGCTGCCGAC TGGGCAATAA AACGCCTACC TGCCCAGTAT CAGCCCGTCT TACTTGAAGC 2640
TAAGCAAGCT TATCTGGGAC AAAAAGAAGA TCACTTGGCC TCACGCGCAG ATCACTTGGA 2700
AGAATTTATT CGCTTTGTGA AAGGCGAGAT CATCAAGTCA GTTGGTAAAT GATGTCTAAC 2760
AATTCGTTCA AGCCGACCGC GCTACGCGCG GCGGCTTAAC TCCGGCGTTA GATGCACTAA 2820
GCACATAATT GCTCACAGCC AAACTATCAG GTCAAGTCTG CTTTTATTAT TTTTAAGCGT 2880
GCATAATAAG CCCTACACAA ATTGGGAGAT ATATCATGAA AGGCTGGCTT TTTCTTGTTA 2940
TCGCAATAGT TGGCGAAGTA ATCGCAACAT CCGCATTAAA ATCTAGCGAG GGCTTTACTA 3000
AGCTTGCCCC TTCCGCCGTT GTCATAATCG GTTATGGCAT CGCATTTTAT TTTCTTTCTC 3060
TGGTTCTGAA ATCCATCCCT GTCGGTGTTG CTTATGCAGT CTGGTCGGGA CTCGGCGTCG 3120
TCATAATTAC AGCCATTGCC TGGTTGCTTC ATGGGCAAAA GCTTGATGCG TGGGGCTTTG 3180
TAGGTATGGG GCTCATAATT GCTGCCTTTT TGCTCGCCCG ATCCCCATCG TGGAAGTCGC 3240
TGCGGAGGCC GACGCCATGG TGACGGTGTT CGGCATTCTG AATCTCACCG AGGACTCCTT 3300
CTTCGATGAG AGCCGGCGGC TAGACCCCGC CGGCGCTGTC ACCGCGGCGA TCGAAATGCT 3360
GCGAGTCGGA TCAGACGTCG TGGATGTCGG ACCGGCCGCC AGCCATCCGG ACGCGAGGCC 3420
TGTATCGCCG GCCGATGAGA TCAGACGTAT TGCGCCGCTC TTAGACGCCC TGTCCGATCA 3480
GATGCACCGT GTTTCAATCG ACAGCTTCCA ACCGGAAACC CAGCGCTATG CGCTCAAGCG 3540
CGGCGTGGGC TACCTGAACG ATATCCAAGG ATTTCCTGAC CCTGCGCTCT ATCCCGATAT 3600
TGCTGAGGCG GACTGCAGGC TGGTGGTTAT GCACTCAGCG CAGCGGGATG GCATCGCCAC 3660
CCGCACCGGT CACCTTCGAC CCGAAGACGC GCTCGACGAG ATTGTGCGGT TCTTCGAGGC 3720
GCGGGTTTCC GCCTTGCGAC GGAGCGGGGT CGCTGCCGAC CGGCTCATCC TCGATCCGGG 3780
GATGGACCGG CGATTGGTCC ATGGCGAAAC GGCCGACCTT GCGCCGACCG GCTTCGGGCA 3840
ACAGGTCCGC GAAGCCATGG ACCAGCGCCG CGAGCATCAT ATCGAACAGC GCGACGCCAC 3900
GCGCAACAGG GACGGCCGAA TCTTCTACCG GCGCAATCTT CTCGCCACCC TGCGCGAGCG 3960
GGAAGTTGCG CGCGCCGGTG CGGAGATGGC CGAGGGCAAG GCGCTGCCGT TCCGCGCCGC 4020
CAAGGATGGT GAGAGCGTCA GCGGCAAGTT TACCGGAACC GTGCATCTAT CGAGCGGCAA 4080
GTTCGCCGTG GTCGAGAAAT CCCATGAGTT CACCCTTGTC CCGTGGCGGC CGATCATCGA 4140
CCGCCAACTC GGCCGCGAGG TTATGGGCAT CGTGCAGGGC GGGTCGGTGT CGTGGCAGTT 4200
AGGGCGGCAG AGGGGGCTGG AACGCTGAGT GCGCCCATGC CGCATTGCGA AGCAAAAGAT 4260
AATCGGATAA AATGTAGCAA TTCATATTCG TAAGCGTGGA GTAATCAGAT GGGAAATTCC 4320
AAGTCAGCAG ACAAGTAAGC CGCAACAACC AGTATTGTTG TTGCGGCGCT CTGTAAGGCT 4380
AGTCTCATCT GATTGCTGAC GAGCAGACGT CGCCCGGTAT TCCTTAATCG AGGGTTGATT 4440
CGTCATGACC ACCACACGCC CCGCGTGGGC CTATACGCTG CCGGCAGCAC TGCTGCTGAT 4500
GGCTCCTTTC GACATCCTCG CTTCACTGGC GATGGATATT TATCTCCCTG TCGTTCCAGC 4560
GATGCCCGGC ATCCTGAACA CGACGCCCGC TATGATCCAA CTCACGTTGA GCCTCTATAT 4620
GGTGATGCTC GGCGTGGGCC AAGTGATTTT TGGTCCGCTC TCAGACAGAA TCGGGCGACG 4680
GCCAATTCTA CTTGCGGGCG CAACGGCTTT CGTCATTGCG TCTCTGGGAG CAGCTTGGTC 4740
TTCAACTGCA CCGGCCTTTG TCGCTTTCCG TCTACTTCAA GCAGTGGGCG CGTCGGCCAT 4800
GCTGGTGGCG ACGTTCGCGA CGGTTCGCGA CGTTTATGCC AACCGTCCTG AGGGTGTCGT 4860
CATCTACGGC CTTTTCAGTT CGATGCTGGC GTTCGTGCCT GCGCTCGGCC CTATCGCCGG 4920
AGCATTGATC GGCGAGTTCT TGGGATGGCA GGCGATATTC ATTACTTTGG CTATACTGGC 4980
GATGCTCGCA CTCCTAAATG CGGGTTTCAG GTGGCACGAA ACCCGCCCTC TGGATCAAGT 5040
CAAGACGCGC CGATCTGTCT TGCCGATCTT CGCGAGTCCG GCTTTTTGGG TTTACACTGT 5100
CGGCTTTAGC GCCGGTATGG GCACCTTCTT CGTCTTCTTC TCGACGGCTC CCCGTGTGCT 5160
CATAGGCCAA GCGGAATATT CCGAGATCGG ATTCAGCTTT GCCTTCGCCA CTGTCGCGCT 5220
TGTAATGATC GTGACAACCC GTTTCGCGAA GTCCTTTGTC GTCAGATGGG GCATCGCAGG 5280
ATGCGTGGCG CGTGGGATGG CGTTGCTTGT TTGCGGAGCG GTCCTGTTGG GGATCGGCGA 5340
ACTTTACGGC TCGCCGTCAT TCCTCACCTT CATCCTACCG ATGTGGGTTG TCGCGGTCGG 5400
TATTGTCTTC ACGGTGTCCG TTACCGCGAA CGGCGCTTTG GCAGAGTTCG ACGACATCGC 5460
GGGATCAGCG GTCGCGTTCT ACTTCTGCAT CCAAAGCCTG ATAGTCAGTA TCGTCGGGAC 5520
ATTGGCGGTG ACGCTGTTAA ACGGCGATAC AGCGTGGCCC GTGATTTGTT ACGCCACGGC 5580
AATGGCAGTG CTGGTGTCGT TGGGGCTGGC GCTCCTTCGA TCCCGTGATG CTGCCACCGA 5640
GAAGTCGCCA GTCGTCTAGC CGACGACTGG AAGCAAGCCC GCTCCGATGC GGCGCAATAA 5700
TCTTCGAAAC CTCGTGAATG GCGGTATCCT GTCTGGCAAG ATACCGCTCA TTTCCCTTGT 5760
CCCGTGGCGG CCGGTCATCG ACCGCCAGCT CGGCCGTGAG GTCATGGGCA TCGTGCAAAG 5820
CGGATCGGTG TCGTGGCAGT TGGGGCGGCA AAGGGGCATA AGCCTCTAAT CTGTTGTAGA 5880
TGAACGCAGC CGCTCGAAAC CAGCGATGAG GCTGTCGAGT CCGAAGTTGA ACGCAGCATC 5940
CATGCCGTCT GTTTCCAACT CGTGAAACAG ATCGTGCAGG AAGGACGACG GTGCTTGCTC 6000
GGACACATCT GGCCTGTCCG GAACTCTCTC ATCGGCATCA GATGCCTGCT GCTCGAGAAC 6060
GGAACCGACC ACATAGTGAC TGACCGCCCG GAGCGCCCAA ACGGCGCGCT TCGGACAAAA 6120
GCCCTCCGCG CAGAGAAAGC GTATTTGCGT CTCGGCGGTG CCAAAATTCG GTTCTGTCGG 6180
TCGAGTGCCG GCATGGATAC GCGCGCCGTC CCGATAAGAG AGCAACGCCG TTCTGAAGCT 6240
CAGGGCATTC TCTTTCAGGA ACACCCGCCA GTCCTCATTC TCTTCGGGTA GCGAGCGGGT 6300
ATGGCGTTCC GCCAGCATCG CCTCGGCGAG CGCATCAAGC AGCGCTCGCT TGTTCTGGAA 6360
ATGCCAGTAA AGCGCAGGCT GCTGAACCTT GAGGCGTTCA GCGAGCTTCC GCGTCGTCAG 6420
GCTGTCCATG CCAACCTCGT TCAACAGCTC TAGCGCCGCC GCGATCACGG TGCCCTTGTC 6480
CAGTTTGGTC ATTCACGTTC CTTCGCCAGT GCTTGACAAT TTATCACCGA TAAGTTATAT 6540
GTCCATCTCC TTATCGTTGA TAAAGTCGCT CCATTGAGCG GCGCTGGAGT TTCAGGTGCG 6600
CAGCTCTGCC ATCATTGCCC TGCTGATCGT GGGTCTTGAC GCCATGGGTC TCGGCCTCAT 6660
CATGCCCGTC CTTCCGACGC TTCTGCGTGA GCTTGTGCCA GCAGAGCAGG TCGCTGGACA 6720
CTATGGTGCC TTGCTGTCGC TCTATGCATT GATGCAGGTC GTCTTCGCGC CCATGCTTGG 6780
ACAGCTTTCG GATTCTTACG GTCGGCGTCC GGTACTTCTG GCTTCTCTTG CAGGAGCCGC 6840
AGTCGATTAC ACGATTATGG CATCAGCGCC GGTCTTATGG GTGCTCTATA TCGGCCGACT 6900
CGTGTCCGGC GTCACGGGCG CAACCGGAGC TGTAGCAGCC TCAACCATTG CCGATTCGAC 6960
GGGGGAAGGT TCTCGCGCAC GCTGGTTCGG CTACATGGGG GCCTGTTATG GGGCGGGCAT 7020
GATTGCCGGG CCAGCACTTG GTGGCATGCT CGGTGGTATC TCTGCTCATG CCCCGTTTAT 7080
CGCCGCCGCC CTTCTCAACG GGTTCGCGTT CCTGCTTGCC TGCATTTTCC TCAAGGAGAC 7140
TCATCACAGC CATGGCGGGA CCGGAAAGCC GGTTCGCATC AAACCATTCG TTCTGTTACG 7200
GCTGGATGAT GCATTGCGCG GGCTAGGTGC GCTTTTCGCA GTTTTCTTCA TTATTCAACT 7260
GATCGGCCAA GTGCCTGCAG CCCTATGGGT CATATATGGC GAGGACCGTT TTCAGTGGAA 7320
CACCGCGACC GTTGGTTTGT CGCTCGCGGC GTTTGGGGCA ACACATGCGA TCTTCCAAGC 7380
GTTTGTTACC GGCCCGCTTT CAAGCCGGCT TGGAGAGCGG CGCACGCTGC TGTTTGGCAT 7440
GGCTGCGGAT GCGACTGGCT TCGTTCTTCT GGCTTTTGCC ACGCAGGGAT GGATGGTGTT 7500
CCCGATTCTG TTGCTGCTTG CCGCCGGGGG TGTTGGCATG CCGGCCTTGC AGGCAATGCT 7560
CTCAAACAAT GTCAGCAGTA ACAAGCAAGG GGCTTTGCAA GGAACGCTAA CGAGCCTCAC 7620
CAATCTAAGC TCTATCGCAG GACCGCTTGG CTTCACAGCA CTCTATTCTG CCACCGCCGG 7680
GGCATGGAAC GGTTGGGTTT GGATTGTCGG CGCGATCCTC TATTTAATAT GTCTGCCAAT 7740
ACTACGCAGA CCATTCGCAA CTTCATTGTG ATTTAGTCAT GGCGATTTGG CATGCGTAGA 7800
CTTAGGAGAA ATGACGGATT AAATCTGTTG AGCAATCATC TCCTTTCGGG GCGAGTGCCA 7860
ATGATGACCT TAGTTCACAC TCTCGCTGTC GCCGAATATC TCAACTTCCG TCACGCCGCC 7920
AACGCGCTCG GCGTTGCACA GTCCAGCGTC AGCGCCCGCG TGAAGGCACT GGAAGAAGAC 7980
CTCGGCATCC TCTTGTTCGA GCGTCATGCG CGCGGCGTTC GGCTGACCGA GGCCGGACGC 8040
CATTTCGTCG AGCGGATAGC CGTAGGTATT GACCAACTCG ACCATGCGGT GAAAACCGCC 8100
GGCATGGCGG CAGCCGGAGA AAGCGGCCGG CTTCGTATCG GTATCCATGC CCTGATTCCG 8160
CATAGCTTCC TCGCAAAGCT GATCGGCCAA TACCGCAAGG ATTACCCCGA TGTTGAAGTC 8220
GAGATCGCCG AAGGCCCGGC CCGTGAAGCG GTGGTGCAGC TTCGCGCCGG CAGGTTGGAC 8280
GTGGCGTTCG TCGCGGGCAC GCCCCAACCA CCCGACTGCC ATTCCCGTCG CACATGGACC 8340
GAACCGCTCT TGGCGGTGCT ACCGGAACGG CATCCGCTCG CCAAGCGGTC AGCCGTCACA 8400
TGGCCCGATT TGGCAGGCGA GACGTTCCTT GCGTATAGGA AGTTCAAACG CCCTTTTCGG 8460
GCAGTCTGCT GGGTAGGCGG CGGTCGCGCA AGCCCCGTTT TGGGCACGGA TCGGACGTCT 8520
GTGAGTGGGA TTTCGGCATC GCGGGGCCAC GCAGCGGCGT TGTCAGCAGC CATGCTTCGC 8580
TGATTCCCGA CAGCGGGCCG AGCGCCGCCC TGCGGATCGT GGCCGCATCG GCTCGGATTC 8640
CGGTTTCGCC GTCGGCTGTG CAGCCGGCAG ATCGTCACGC GGCTTGCACT GGCGGCGCGC 8700
GCGCTGCGGG CCTGTAGTGC GCTTCTTCCC GCGCGCCGTG CTTCTCGAAG TGGGCGAGGA 8760
TGGCGCGGAT GGCGGTGGGT TCCTCGATGC TGGCGACGAT CCGCCGGTGC CACCGCAGTG 8820
GACGCAGGCG GTGACGTCGA TGGAAAAGAC CCGCTTGAGC CGTTGCGCCC AGCTCATCGC 8880
ACGGCGCTTC TCCTCGGGGC TGCGCGGCGC GTCGTGGGCG CTGACGTCCA CTGGCGCCGC 8940
ATCGCCCGCA GGCCGCTTGC CGCGCCCCGA GGGCGTCAGC TGCGCACGCA GGTTTGCATT 9000
CGGGGCGAAT ACGCCGTGGA AGCGGGTGAG ATGCGCGCGA GGTGGCGGGA CCAGCGCCGC 9060
CAGCTTGGCG ATGAAATCCA CCGGATCCCA TTCCACATGC GTGGTGCCAT TGCGCCACGG 9120
GGTCTTGAGC TGGTAACGCA CCCTGCCCTG GAGCGCTATC GACAGCCGCT TCTCGCTGAT 9180
CGCCGGGCGC GTGATGTAGC GGCACAGCTT TTCCAGCTTG TGGCTTTCGT GTGCTTCGGC 9240
CGCCACGCCG GCATGCAGTG AGAAGCCGCC GACCTTGCCG GCTTCGCCCT CCAGCGAACC 9300
GGCGTCACCG GGCAGCGTTT GCAGCGTGAC GACCTTGCAG CCAGCGTCGC GGCCGGTGGC 9360
GATGCGGTAG GTGATCGAAC TCATCCGCAG CCCATCCATG CTGTCGTCGC CTGCAGCGCT 9420
GTCTGCCAGG AAGGCCGATT CGCCCTCCCC TTCGAGCCAG CCTTTGCGCG TCAGGTGCCG 9480
ACACACCCGG TGCGCGATGG TAGCTGCCAG CTGGGTCAAC TGCGCGGTGG TGGGCGCACG 9540
GGCGCGGTGC AGGCGCAGTT CGCGCCGCGG CAGCTCGGTG GCTTCCACGT ACACGCCGTC 9600
GAGCCACAGC ATGTGGAAGT GGATGTTCAG GTTCAGCGCG CTGCCGAAAC GCTGGATCAG 9660
CGTCACCGCG CCGCACTGGG CGCTGGCGCG GTCGATGCCG GCTTGATCGG CCAACCAGCC 9720
GGCGATCACG CGCTGCACGA TGCCCAGCAC CGGGCCAATG GCTTCTGGCT TGCTGGCGAA 9780
CAGGAAACGC AAGGGGTACG GAAAGCTCAG CACCCATTGC CGCACAGGCC GCGGGCCGAA 9840
CACCTCCTCG ACCAGGTGCC GCGCACTCTC GGCCATGCGT CGCGCGCCGC AACTCGGGCA 9900
GAACCCGCGC TTCTTGCAGG AGAAGGCCAC CAGCCTCTCT GCACGGCAGT GCTCGCACAC 9960
CACCCGCAGG AAGCCGTGCT CGAGTACGCC GCAACGCAGG TAGGCATCGA ACGCCTCGCG 10020
GACATACCCG GGCAGCGAGC GGCCCTCCGC TTCGATCCGT GCAATGAAGT CCGGGTAGTG 10080
CGCCTCTACC AACGCGTACA GCAGCGTGCG CTCGGGCGCG TGGCGCGCGT ACCGCGAACC 10140
GGTGTGGGCG GACGGCAGTG GCGCGCATCC CGCGGCTTGC CGCCGGGATG TGGCGAGGCG 10200
CGGCACGCAG CGCTCCGGTG CGGGGACGGC TGCTCAGTGT TGCGCCTGTG TTCGCACGTT 10260
CGTATCGGTG CGTTCTGATC TTCGCGTCAG ACATTGCCGC GGCGCGGGCA CAACAAAAAG 10320
CCCGGCATCG CTGCCGGGCT CCGGCCCCGT CCTTGGGGCC TTGATGTCGG GTCGTTGCCG 10380
GGATCGGACC GCGCTGGCGC GGTCCGGTTC CCTGACGACC GGGCCAACCG GATCAGAAAT 10440
CCATGCCGCC CATGCCGCCC ATACCGCCAG CACCCGGCAT GGCCGGCTCT TCCTTCTTCG 10500
GCACTTCGGC CACGACCACT TCGGTCGTGA TCGCAAGGCC GGCGACGGAA GCGGCGTGCT 10560
GCAGGGCCGA GCGGGTCACC TTGGTCGGGT CCAGGATGCC CATGGCGATC ATGTCGCCGA 10620
ACTCGCCGGT GGCGGCGTTG TAGCCGTAGC TGCCTTCGCC GGCCTTGACG TTGGCCACGA 10680
TCACGCTCGG TTCTTCACCG GCGTTGGCCA CGATGGCGCG CAGCGGGGCT TCCAGCGCAC 10740
GGCGGGTGAT GGCGATGCCC AGGTTCTGGT CTTCGTTGAT GCCCTGCCAG GGCAGATCCG 10800
TGCACAGCAC CTTGCCGTAG AAGAACAGCA AGGCCGCCAA TGCCTGACGA TGCGTGGAGA 10860
CCGAAACCTT GCGCTCGTTC GCCAGCCAGG ACAGAAATGC CTCGACTTCG CTGCTGCCCA 10920
AGGTTGCCGG GTGACGCACA CCGTGGAAAC GGATGAAGGC ACGAACCCAG TGGACATAAG 10980
CCTGTTCGGT TGGTAAGCTG TAATGCAAGT AGCGTATGCG CTCACGCAAC TGGTCCAGAA 11040
CCTTGACCGA ACGCAGCGGT GGTAACGGCG CAGTGGCGGT TTTCATGGCT TGTTATGACT 11100
GTTTTTTTGT ACAGTCTATG CCTCGGGCAT CCAAGCAGCA AGCGCGTTAC GCCGTGGGTC 11160
GATGTTTGAT GTTATGGAGC AGCAACGATG TTACGCAGCA GGGCAGTCGC CCTAAAACAA 11220
AGTTAGCCAT ATTATGGAGC CTCATGCTTT TATATAAAAT GTGTGACAAT CAAAATTATG 11280
GGGTTACTTA CATGAAGTTT TTATTGGCAT TTTCGCTTTT AATACCATCC GTGGTTTTTG 11340
CAAGTAGTTC AAAGTTTCAG CAAGTTGAAC AAGACGTTAA GGCAATTGAA GTTTCTCTTT 11400
CTGCTCGTAT AGGTGTTTCC GTTCTTGATA CTCAAAATGG AGAATATTGG GATTACAATG 11460
GCAATCAGCG CTTCCCGTTA ACAAGTACTT TTAAAACAAT AGCTTGCGCT AAATTACTAT 11520
ATGATGCTGA GCAAGGAAAA GTTAATCCCA ATAGTACAGT CGAGATTAAG AAAGCAGATC 11580
TTGTGACCTA TTCCCCTGTA ATAGAAAAGC AAGTAGGGCA GGCAATCACA CTCGATGATG 11640
CGTGCTTCGC AACTATGACT ACAAGTGATA ATACTGCGGC AAATATCATC CTAAGTGCTG 11700
TAGGTGGCCC CAAAGGCGTT ACTGATTTTT TAAGACAAAT TGGGGACAAA GAGACTCGTC 11760
TAGACCGTAT TGAGCCTGAT TTAAATGAAG GTAAGCTCGG TGATTTGAGG GATACGACAA 11820
CTCCTAAGGC AATAGCCAGT ACTTTGAATA AATTTTTATT TGGTTCCGCG CTATCTGAAA 11880
TGAACCAGAA AAAATTAGAG TCTTGGATGG TGAACAATCA AGTCACTGGT AATTTACTAC 11940
GTTCAGTATT GCCGGCGGGA TGGAACATTG CGGATCGCTC AGGTGCTGGC GGATTTGGTG 12000
CTCGGAGTAT TACAGCAGTT GTGTGGAGTG AGCATCAAGC CCCAATTATT GTGAGCATCT 12060
ATCTAGCTCA AACACAGGCT TCAATGGCAG AGCGAAATGA TGCGATTGTT AAAATTGGTC 12120
ATTCAATTTT TGACGTTTAT ACATCACAGT CGCGCTGATA AGGCTAACAA GGCCATCAAG 12180
TTGACGGCTT TTCCGTCGCT TGTTTTGTGG TTTAACGCTA CGCTACCACA AAACAATCAA 12240
CTCCAAAGCC GCAACTTATG GCGGCGTTAG ATGCACTAAG CACATAATTG CTCACAGCCA 12300
AACTATCAGG TCAAGTCTGC TTTTATTATT TTTAAGCGTG CATAATAAGC CCTACACAAA 12360
TTGGGAGATA TATCATGAAA GGCTGGCTTT TTCTTGTTAT CGCAATAGTT GGCGAAGTAA 12420
TCGCAACATC CGCATTAAAA TCTAGCGAGG GCTTTACTAA GCTTGCCCCT TCCGCCGTTG 12480
TCATAATCGG TTATGGCATC GCATTTTATT TTCTTTCTCT GGTTCTGAAA TCCATCCCTG 12540
TCGGTGTTGC TTATGCAGTC TGGTCGGGAC TCGGCGTCGT CATAATTACA GCCATTGCCT 12600
GGTTGCTTCA TGGGCAAAAG CTTGATGCGT GGGGCTTTGT AGGTATGGGG CTCATAATTG 12660
CTGCCTTTTT GCTCGCCCGA TCCCCATCGT GGAAGTCGCT GCGGAGGCCG ACGCCATGGT 12720
GACGGTGTTC GGCATTCTGA ATCTCACCGA GGACTCCTTC TTCGATGAGA GCCGGCGGCT 12780
AGACCCCGCC GGCGCTGTCA CCGCGGCGAT CGAAATGCTG CGAGTCGGAT CAGACGTCGT 12840
GGATGTCGGA CCGGCCGCCA GCCATCCGGA CGCGAGGCCT GTATCGCCGG CCGATGAGAT 12900
CAGACGTATT GCGCCGCTCT TAGACGCCCT GTCCGATCAG ATGCACCGTG TTTCAATCGA 12960
CAGCTTCCAA CCGGAAACCC AGCGCTATGC GCTCAAGCGC GGCGTGGGCT ACCTGAACGA 13020
TATCCAAGGA TTTCCTGACC CTGCGCTCTA TCCCGATATT GCTGAGGCGG ACTGCAG 13077
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