Tetracycline resistance gene classification: Class H

© Service of Biosafety & Biotechnology - Author: Jean-Marc Collard
Last revised: January 11, 1999


MECHANISM

Efflux 12-TMS (Transmembrane segments)
    Ribosomal protection  
    Enzymatic  
    Unknown  

MINOCYCLINE RESISTANCE

YES

 

NO



DISTRIBUTION Pasteurella


REPRESENTATIVES pVM111 (Ref. 1) Tn5706 (Ref. 4)
GENETIC LOCATION Plasmid (and chromosome: see Ref. 3) Transposon from pPMT1 plasmid
SOURCE Pasteurella multocida P2862 Pasteurella multocida
SEQUENCE ACCESS NB U00792 (Ref. 2) Y15510

REPRESENTATIVES pPHT1
GENETIC LOCATION Plasmid  
SOURCE Pasteurella multocida
SEQUENCE ACCESS NB Y16103 (Unpublished)

PROTEIN WEIGHT
PROBES 4-kb BstNI from pVM111 (Ref. 2)
PCR PRIMERS see reference 3


  REFERENCES
1 Hirsh, D. C., L. D. Martin, and K. R. Rhoades. 1985. Resistance plasmids of Pasteurella multocida isolated from turkeys. Am. J. Vet. Res. 46:1490-1493.
2 Hansen, L. M., L. M. Mcmurry, S. B. Levy, and D. C. Hirsh. 1993. A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline. Antimicrob. Agents Chemother. 37:2699-2705.
3 Hansen, L. M., P. C. Blanchard, and D. C. Hirsh. 1996. Distribution of tet(H) among Pasteurella isolates from the United States and Canada. Antimicrob. Agents Chemother. 40:1558-1560.
4 Kehrenberg, C., C. Werckenthin, and S. Schwarz. 1998. Tn5706, a transposon-like element from Pasteurella multocida mediating tetracycline resistance. Antimicrob. Agents Chemother. 42:2116-2118.