Tetracycline determinants: Class P(A)

Tetracycline resistance gene classification: Class P(A)

© Service of Biosafety & Biotechnology - Author: Jean-Marc Collard
Last revised: July 5, 1998

MECHANISM	Efflux	12-TMS (Transmembrane segments)
	Ribosomal protection
	Enzymatic
	Unknown

MINOCYCLINE RESISTANCE

YES

DISTRIBUTION

Clostridium, Helicobater

REPRESENTATIVES	pCW3 (Ref. 1, 2, 3)
GENETIC LOCATION	Plasmid
SOURCE	Clostridium perfringens	Clostridium perfringens
SEQUENCE ACCESS NB	L20800 (Ref. 2)	AB001076 (Unpublished)

PROTEIN WEIGHT	46 kDa (Calculated) (Ref. 2)
PROBES	0.9-kb SphI-EcoRI fragment of pJIR666 (Ref. 3)
PCR PRIMERS	see reference 3

REFERENCES

1 Saksena, N. K., and N. Truffaut. 1993. Identification of the product of tetP gene - a possible mechanistic basis for tetracycline resistance in Clostridium perfringens. Folia Microbiol. 38:15-21.

2 Sloan, J., L. M. Mcmurry, D. Lyras, S. B. Levy, and J. I. Rood. 1994. The Clostridium perfringens Tet P determinant comprises two overlapping genes - tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants. Mol. Microbiol. 11:403-415.

3 Lyras, D., and J. I. Rood. 1996. Genetic organization and distribution of tetracycline resistance determinants in Clostridium perfringens. Antimicrob. Agents Chemother. 40:2500-2504.

	REFERENCES
1	Saksena, N. K., and N. Truffaut. 1993. Identification of the product of tetP gene - a possible mechanistic basis for tetracycline resistance in Clostridium perfringens. Folia Microbiol. 38:15-21.
2	Sloan, J., L. M. Mcmurry, D. Lyras, S. B. Levy, and J. I. Rood. 1994. The Clostridium perfringens Tet P determinant comprises two overlapping genes - tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants. Mol. Microbiol. 11:403-415.
3	Lyras, D., and J. I. Rood. 1996. Genetic organization and distribution of tetracycline resistance determinants in Clostridium perfringens. Antimicrob. Agents Chemother. 40:2500-2504.