Tetracycline determinants: OtrA

Tetracycline resistance gene classification: otrA

© Service of Biosafety & Biotechnology - Author: Jean-Marc Collard
Last revised: March 3, 1998

MECHANISM		Efflux
		Ribosomal protection
		Enzymatic
		Unknown

MINOCYCLINE RESISTANCE

YES

DISTRIBUTION

Gram-positives: Streptomyces, Mycobacterium

REPRESENTATIVES	otrA
GENETIC LOCATION	Chromosome
SOURCE	Streptomyces rimosus
SEQUENCE ACCESS NB	X53401 (Ref. 1)

PROTEIN WEIGHT
PROBES
PCR PRIMERS

REFERENCES

1 Doyle, D., K. J. McDowall, M. J. Butler, and I. S. Hunter. 1991. Characterization of an oxytetracycline-resistance gene, otrA, of Streptomyces rimosus. Mol. Microbiol. 5:2923-2933.

2 Pang, Y., B.A. Brown, V.A. Steingrube, R.J. Wallace, and M.C. Roberts. 1994. Tetracycline resistance determinants in Mycobacterium and Streptomyces species. Antimicrob. Agents Chemother. 38:1408-1412.

	REFERENCES
1	Doyle, D., K. J. McDowall, M. J. Butler, and I. S. Hunter. 1991. Characterization of an oxytetracycline-resistance gene, otrA, of Streptomyces rimosus. Mol. Microbiol. 5:2923-2933.
2	Pang, Y., B.A. Brown, V.A. Steingrube, R.J. Wallace, and M.C. Roberts. 1994. Tetracycline resistance determinants in Mycobacterium and Streptomyces species. Antimicrob. Agents Chemother. 38:1408-1412.