Tetracycline determinants: OtrB

Tetracycline resistance gene classification: otrB

© Service of Biosafety & Biotechnology - Author: Jean-Marc Collard
Last revised: November 17, 1998

MECHANISM		Efflux
		Ribosomal protection
		Enzymatic
		Unknown

MINOCYCLINE RESISTANCE

YES

DISTRIBUTION

Streptomyces

REPRESENTATIVES	otrB (tet347)
GENETIC LOCATION	Chromosome
SOURCE	Streptomyces rimosus
SEQUENCE ACCESS NB	AF079900

PROTEIN WEIGHT	35.8 kDa (Calculated) (Ref. 1)
PROBES
PCR PRIMERS

REFERENCE

1 Reynes, J. P., T. Calmels, D. Drocourt, and G. Tiraby. 1988. Cloning expression in Escherichia coli and nucleotide sequence of a tetracycline-resistance gene from Streptomyces rimosus. J. Gen. Microbiol. 134:585-598.

2 McMurry, L.M. and S. B. Levy. 1998. Revised sequence of OtrB (Tet347) tetracycline efflux protein from Streptomyces rimosus. Antimicrob. Agents Chemother. 42 (11):3050.

	REFERENCE
1	Reynes, J. P., T. Calmels, D. Drocourt, and G. Tiraby. 1988. Cloning expression in Escherichia coli and nucleotide sequence of a tetracycline-resistance gene from Streptomyces rimosus. J. Gen. Microbiol. 134:585-598.
2	McMurry, L.M. and S. B. Levy. 1998. Revised sequence of OtrB (Tet347) tetracycline efflux protein from Streptomyces rimosus. Antimicrob. Agents Chemother. 42 (11):3050.